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Structure of the month - September 2007

Wollert_September07_fig1 - enlarged view

Figure 1. Comparison of InlA/hEC1 (human, blue) and InlAm/mEC1 (murine, red) complexes. Critical substitutions between human and murine EC1 domains are shown as ball-and-stick, solvent-exposed substitutions as spheres (differences involving charged residues are marked in red and blue, all others in beige).

Wollert_September07_fig2 - enlarged view

Figure 2. The carboxylate of Glu16mEC1, well defined in the 2FO-FC difference electron density (blue, contoured at 1σ), is forced to occupy the hydrophobic Pro16hEC1 binding pocket of InlA.

Wollert_September07_tab1 - enlarged view

Table 1. X-ray data collection and refinement statistics.