Joint Research Group Macromolecular Crystallography
Structure of the month - February 2004
Proteins: Structure, Function and Bioinformatics Vol. 54, 2004, Pages 797-800
Crystal structure of Homo sapiens protein hp14.5
Babu A. Manjasetty#, Heinrich Delbrück#, Dinh-Trung Pham#, Uwe Mueller#, Martin Fieber-Erdmann#, Christoph Scheich#, Volker Sievert#, Konrad Büssow#, Frank Niesen#, Wilhelm Weihofen*, Bernhard Loll*, Wolfram Saenger#*, Udo Heinemann#§
# Proteinstrukturfabrik, Heubnerweg 6, Geb.D, 14059-Berlin, Germany
* Forschungsgruppe Kristallographie, Freie Universität Berlin, Takustr.6, 14195-Berlin, Germany
§ Forschungsgruppe Kristallographie, Max-Delbrück-Centrum für Molekulare Medizin Berlin, Robert-Roessle-Str.10, 13125-Berlin, Germany
Abstract
Human trichloroacetic acid-soluble protein p14.5 (hp14.5) is a member of the large YjgF/YER057c/UK114 protein family which comprises approximately 200 members, most with unclear biological function. The crystal structures of three distant homologs have been determined recently: YabJ from Bacillus subtilis (45% identity), YjgF from Escherichia coli (46%) and Yeo7 from yeast (39%). These proteins share similar homo-trimeric structures and distinct clefts located between the subunits which may be of functional relevance.