HZB-MX related Publications and Structures

This page lists 1565 publications with direct reference to 3994 PDB structures (out of 4887 released) citing the X-ray diffraction experiments at the HZB-MX beamlines. The sort order is by electronic publication date, with the latest one at the top.

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Publications and Structures from Bessy-MX

• Crystal structure of the feruloyl esterase from Lentilactobacillus buchneri reveals a novel homodimeric state
  Kasmaei, K.M.; Kalyani, D.C.; Reichenbach, T.; Jimenez-Quero, A.; Vilaplana, F.; Divne, C.
  Front Microbiol (13), 1050160-1050160 (2022)
  DOI: 10.3389/fmicb.2022.1050160
  PubMed ID: 36569051
  

• BAY-7081: A Potent, Selective, and Orally Bioavailable Cyanopyridone-Based PDE9A Inhibitor
  Meibom, D.; Micus, S.; Andreevski, A.L.; Anlauf, S.; Bogner, P.; von Buehler, C.J.; Dieskau, A.P.; Dreher, J.; Eitner, F.; Fliegner, D.; Follmann, M.; Gericke, K.M.; Maassen, S.; Meyer, J.; Schlemmer, K.H.; Steuber, H.; Tersteegen, A.; Wunder, F.
  J Med Chem (65), 16420-16431 (2022)
  DOI: 10.1021/acs.jmedchem.2c01267
  PubMed ID: 36475653
  

• A growth selection system for the directed evolution of amine-forming or converting enzymes
  Wu, S.; Xiang, C.; Zhou, Y.; Khan, M.S.H.; Liu, W.; Feiler, C.G.; Wei, R.; Weber, G.; Hohne, M.; Bornscheuer, U.T.
  Nat Commun (13), 7458-7458 (2022)
  DOI: 10.1038/s41467-022-35228-y
  PubMed ID: 36460668
  

• Thermodynamic and structural characterization of an optimized peptide-based inhibitor of the influenza polymerase PA-PB1 subunit interaction
  Radilova, K.; Zima, V.; Kral, M.; Machara, A.; Majer, P.; Hodek, J.; Weber, J.; Brynda, J.; Strmen, T.; Konvalinka, J.; Kozisek, M.
  Antiviral Res (208), 105449-105449 (2022)
  DOI: 10.1016/j.antiviral.2022.105449
  PubMed ID: 36265804
  

• Structural Insights into (Tere)phthalate-Ester Hydrolysis by a Carboxylesterase and Its Role in Promoting PET Depolymerization
  Von Haugwitz, G.; Han, X.; Pfaff, L.; Li, Q.; Wei, H.; Gao, J.; Methling, K.; Ao, Y.; Brack, Y.; Mican, J.; Feiler, C.G.; Weiss, M.S.; Bednar, D.; Palm, G.J.; Lalk, M.; Lammers, M.; Damborsky, J.; Weber, G.; Liu, W.; Bornscheuer, U.T.; Wei, R.
  ACS Catal (12), 15259-15270 (2022)
  DOI: 10.1021/acscatal.2c03772
  

• Investigation of the halophilic PET hydrolase PET6 from Vibrio gazogenes
  Weigert, S.; Perez-Garcia, P.; Gisdon, F.J.; Gagsteiger, A.; Schweinshaut, K.; Ullmann, G.M.; Chow, J.; Streit, W.R.; Hocker, B.
  Protein Sci (31), e4500-e4500 (2022)
  DOI: 10.1002/pro.4500
  PubMed ID: 36336469
  

• Water Network in the Binding Pocket of Fluorinated BPTI-Trypsin Complexes?Insights from Simulation and Experiment
  Wehrhan, L.; Leppkes, J.; Dimos, N.; Loll, B.; Koksch, B.; Keller, B.G.
  J Phys Chem B (126), 9985-9999 (2022)
  DOI: 10.1021/acs.jpcb.2c05496
  PubMed ID: 36409613
  

• Dynamic Long-Range Interactions Influence Substrate Binding and Catalysis by Human Histidine Triad Nucleotide-Binding Proteins (HINTs), Key Regulators of Multiple Cellular Processes and Activators of Antiviral ProTides
  Strom, A.; Shah, R.; Dolot, R.; Rogers, M.S.; Tong, C.L.; Wang, D.; Xia, Y.; Lipscomb, J.D.; Wagner, C.R.
  Biochemistry (61), 2648-2661 (2022)
  DOI: 10.1021/acs.biochem.2c00506
  PubMed ID: 36398895
  

• Structural Basis for (2 R ,3 R )-Taxifolin Binding and Reaction Products to the Bacterial Chalcone Isomerase of Eubacterium ramulus
  Palm, G.J.; Thomsen, M.; Berndt, L.; Hinrichs, W.
  Molecules (27) (2022)
  DOI: 10.3390/molecules27227909
  PubMed ID: 36432010
  

• Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates
  Miller, M.; Rossetti, T.; Ferreira, J.; Ghanem, L.; Balbach, M.; Kaur, N.; Levin, L.R.; Buck, J.; Kehr, M.; Coquille, S.; van den Heuvel, J.; Steegborn, C.; Fushimi, M.; Finkin-Groner, E.; Myers, R.W.; Kargman, S.; Liverton, N.J.; Huggins, D.J.; Meinke, P.T.
  J Med Chem (65), 15208-15226 (2022)
  DOI: 10.1021/acs.jmedchem.2c01133
  PubMed ID: 36346696
  

• Binding pocket stabilization by high-throughput screening of yeast display libraries
  Lerma Romero, J.A.; Meyners, C.; Christmann, A.; Reinbold, L.M.; Charalampidou, A.; Hausch, F.; Kolmar, H.
  Front Mol Biosci (9), 1023131-1023131 (2022)
  DOI: 10.3389/fmolb.2022.1023131
  PubMed ID: 36419931
  

• Structure and thermodynamics of a UGG motif interacting with Ba2+ and other metal ions: accommodating changes in the RNA structure and the presence of a G(syn)-G(syn) pair
  Kiliszek, A.; Pluta, M.; Bejger, M.; Rypniewski, W.
  RNA (29), 44-54 (2022)
  DOI: 10.1261/rna.079414.122
  PubMed ID: 36319090
  

• Molecular Mechanism of Sirtuin 1 Modulation by the AROS Protein
  Weiss, S.; Adolph, R.S.; Schweimer, K.; DiFonzo, A.; Meleshin, M.; Schutkowski, M.; Steegborn, C.
  Int J Mol Sci (23) (2022)
  DOI: 10.3390/ijms232112764
  PubMed ID: 36361557
  

• BAY-069, a Novel (Trifluoromethyl)pyrimidinedione-Based BCAT1/2 Inhibitor and Chemical Probe
  Gunther, J.; Hillig, R.C.; Zimmermann, K.; Kaulfuss, S.; Lemos, C.; Nguyen, D.; Rehwinkel, H.; Habgood, M.; Lechner, C.; Neuhaus, R.; Ganzer, U.; Drewes, M.; Chai, J.; Bouche, L.
  J Med Chem (65), 14366-14390 (2022)
  DOI: 10.1021/acs.jmedchem.2c00441
  PubMed ID: 36261130
  

• On the Kinetics of CO2 Reduction by Ni, Fe-CO Dehydrogenases
  Ruickoldt, J.; Basak, Y.; Domnik, L.; Jeoung, J.H.; Dobbek, H.
  Acs Catal (2022)
  DOI: 10.1021/acscatal.2c02221
  

• Substrate Activation at the Ni,Fe Cluster of CO Dehydrogenases: The Influence of the Protein Matrix
  Basak, Y.; Jeoung, J.H.; Domnik, L.; Ruickoldt, J.; Dobbek, H.
  ACS Catal (2022)
  DOI: 10.1021/acscatal.2c02922
  

• Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists
  Vavrina, Z.; Perlikova, P.; Milisavljevic, N.; Chevrier, F.; Smola, M.; Smith, J.; Dejmek, M.; Havlicek, V.; Budesinsky, M.; Liboska, R.; Vanekova, L.; Brynda, J.; Boura, E.; Rezacova, P.; Hocek, M.; Birkus, G.
  J Med Chem (65), 14082-14103 (2022)
  DOI: 10.1021/acs.jmedchem.2c01305
  PubMed ID: 36201304
  

• Mechanistic insight into the RNA-stimulated ATPase activity of tick-borne encephalitis virus helicase
  Anindita, P.D.; Halbeisen, M.; Reha, D.; Tuma, R.; Franta, Z.
  J Biological Chem (298), 102383-102383 (2022)
  DOI: 10.1016/j.jbc.2022.102383
  PubMed ID: 35987382
  

• Model of abasic site DNA cross-link repair; from the architecture of NEIL3 DNA binding domains to the X-structure model
  Huskova, A.; Dinesh, D.C.; Srb, P.; Boura, E.; Veverka, V.; Silhan, J.
  Nucleic Acids Res (50), 10436-10448 (2022)
  DOI: 10.1093/nar/gkac793
  PubMed ID: 36155818
  

• E2/E3-independent ubiquitin-like protein conjugation by Urm1 is directly coupled to cysteine persulfidation
  Ravichandran, K.E.; Kaduhr, L.; Skupien-Rabian, B.; Shvetsova, E.; Sokolowski, M.; Krutyholowa, R.C.; Kwasna, D.; Brachmann, C.; Lin, S.; Guzman Perez, S.; Wilk, P.; Kosters, M.; Grudnik, P.; Jankowska, U.; Leidel, S.A.; Schaffrath, R.; Glatt, S.
  EMBO J (41), e111318-e111318 (2022)
  DOI: 10.15252/embj.2022111318
  PubMed ID: 36102610
  

• Crystal structures of free and ligand-bound forms of the TetR/AcrR-like regulator SCO3201 from Streptomyces coelicolor suggest a novel allosteric mechanism
  Werten, S.; Waack, P.; Palm, G.J.; Virolle, M.J.; Hinrichs, W.
  FEBS J (2022)
  DOI: 10.1111/febs.16606
  PubMed ID: 36017630
  

• Crystal structure of the Escherichia coli CusS kinase core
  Cociurovscaia, A.; Bujacz, G.; Pietrzyk-Brzezinska, A.J.
  J Struct Biol (214), 107883-107883 (2022)
  DOI: 10.1016/j.jsb.2022.107883
  PubMed ID: 35907487
  

• Structural insights into crista junction formation by the Mic60-Mic19 complex
  Bock-Bierbaum, T.; Funck, K.; Wollweber, F.; Lisicki, E.; von der Malsburg, K.; von der Malsburg, A.; Laborenz, J.; Noel, J.K.; Hessenberger, M.; Jungbluth, S.; Bernert, C.; Kunz, S.; Riedel, D.; Lilie, H.; Jakobs, S.; van der Laan, M.; Daumke, O.
  Sci Adv (8), eabo4946-eabo4946 (2022)
  DOI: 10.1126/sciadv.abo4946
  PubMed ID: 36044574
  

• Pronounced sequence specificity of the TET enzyme catalytic domain guides its cellular function
  Ravichandran, M.; Rafalski, D.; Davies, C.I.; Ortega-Recalde, O.; Nan, X.; Glanfield, C.R.; Kotter, A.; Misztal, K.; Wang, A.H.; Wojciechowski, M.; Razew, M.; Mayyas, I.M.; Kardailsky, O.; Schwartz, U.; Zembrzycki, K.; Morison, I.M.; Helm, M.; Weichenhan, D.; Jurkowska, R.Z.; Krueger, F.; Plass, C.; Zacharias, M.; Bochtler, M.; Hore, T.A.; Jurkowski, T.P.
  Sci Adv (8), eabm2427-eabm2427 (2022)
  DOI: 10.1126/sciadv.abm2427
  PubMed ID: 36070377
  

• The superior salinity tolerance of bread wheat cultivar Shanrong No. 3 is unlikely to be caused by elevated Ta-sro1 poly-(ADP-ribose) polymerase activity
  Vogt, S.; Feijs, K.; Hosch, S.; De Masi, R.; Lintermann, R.; Loll, B.; Wirthmueller, L.
  Plant Cell (34), 4130-4137 (2022)
  DOI: 10.1093/plcell/koac261
  PubMed ID: 35980152
  

• Structures of UBA6 explain its dual specificity for ubiquitin and FAT10
  Truongvan, N.; Li, S.; Misra, M.; Kuhn, M.; Schindelin, H.
  Nat Commun (13), 4789-4789 (2022)
  DOI: 10.1038/s41467-022-32040-6
  PubMed ID: 35970836
  

• Crystal structure of SARS-CoV-2 nsp10-nsp16 in complex with small molecule inhibitors, SS148 and WZ16
  Klima, M.; Khalili Yazdi, A.; Li, F.; Chau, I.; Hajian, T.; Bolotokova, A.; Kaniskan, H.U.; Han, Y.; Wang, K.; Li, D.; Luo, M.; Jin, J.; Boura, E.; Vedadi, M.
  Protein Sci (31), e4395-e4395 (2022)
  DOI: 10.1002/pro.4395
  PubMed ID: 36040262
  

• Diadenosine tetraphosphate regulates biosynthesis of GTP in Bacillus subtilis
  Giammarinaro, P.I.; Young, M.K.M.; Steinchen, W.; Mais, C.N.; Hochberg, G.; Yang, J.; Stevenson, D.M.; Amador-Noguez, D.; Paulus, A.; Wang, J.D.; Bange, G.
  Nat Microbiol (7), 1442-1452 (2022)
  DOI: 10.1038/s41564-022-01193-x
  PubMed ID: 35953658
  

• Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors
  Specker, E.; Matthes, S.; Wesolowski, R.; Schutz, A.; Grohmann, M.; Alenina, N.; Pleimes, D.; Mallow, K.; Neuenschwander, M.; Gogolin, A.; Weise, M.; Pfeifer, J.; Ziebart, N.; Heinemann, U.; von Kries, J.P.; Nazare, M.; Bader, M.
  J Med Chem (65), 11126-11149 (2022)
  DOI: 10.1021/acs.jmedchem.2c00598
  PubMed ID: 35921615
  

• Improving the selectivity of 3-amidinophenylalanine-derived matriptase inhibitors
  Pilgram, O.; Keils, A.; Benary, G.E.; Muller, J.; Merkl, S.; Ngaha, S.; Huber, S.; Chevillard, F.; Harbig, A.; Magdolen, V.; Heine, A.; Bottcher-Friebertshauser, E.; Steinmetzer, T.
  Eur J Med Chem, 114437 (2022)
  DOI: 10.1016/j.ejmech.2022.114437
  

• Binding Adaptation of GS-441524 Diversifies Macro Domains and Downregulates SARS-CoV-2 de-MARylation Capacity
  Tsika, A.C.; Gallo, A.; Fourkiotis, N.K.; Argyriou, A.I.; Sreeramulu, S.; Lohr, F.; Rogov, V.V.; Richter, C.; Linhard, V.; Gande, S.L.; Altincekic, N.; Krishnathas, R.; Elamri, I.; Schwalbe, H.; Wollenhaupt, J.; Weiss, M.S.; Spyroulias, G.A.
  J Mol Biology (434), 167720-167720 (2022)
  DOI: 10.1016/j.jmb.2022.167720
  PubMed ID: 35839840
  

• Structural basis for coupled ATP-driven electron transfer in the double-cubane cluster protein
  Jeoung, J.H.; Nicklisch, S.; Dobbek, H.
  Proc Natl Acad Sci U S A (119), e2203576119-e2203576119 (2022)
  DOI: 10.1073/pnas.2203576119
  PubMed ID: 35905315
  

• Multiple Substrate Binding Mode-Guided Engineering of a Thermophilic PET Hydrolase
  Pfaff, L.; Gao, J.; Li, Z.; Jackering, A.; Weber, G.; Mican, J.; Chen, Y.; Dong, W.; Han, X.; Feiler, C.G.; Ao, Y.F.; Badenhorst, C.P.S.; Bednar, D.; Palm, G.J.; Lammers, M.; Damborsky, J.; Strodel, B.; Liu, W.; Bornscheuer, U.T.; Wei, R.
  ACS Catal (12), 9790-9800 (2022)
  DOI: 10.1021/acscatal.2c02275
  PubMed ID: 35966606
  

• HUG Domain Is Responsible for Active Dimer Stabilization in an NrdJd Ribonucleotide Reductase
  Fietze, T.; Wilk, P.; Kabinger, F.; Anoosheh, S.; Hofer, A.; Lundin, D.; Feiler, C.G.; Weiss, M.S.; Loderer, C.
  Biochemistry (61), 1633-1641 (2022)
  DOI: 10.1021/acs.biochem.2c00173
  PubMed ID: 35856337
  

• De novo designed peptides for cellular delivery and subcellular localisation
  Rhys, G.G.; Cross, J.A.; Dawson, W.M.; Thompson, H.F.; Shanmugaratnam, S.; Savery, N.J.; Dodding, M.P.; Hocker, B.; Woolfson, D.N.
  Nat Chem Biol (18), 999-1004 (2022)
  DOI: 10.1038/s41589-022-01076-6
  PubMed ID: 35836017
  

• Structural and Biochemical Investigation of the Heterodimeric Murine tRNA-Guanine Transglycosylase
  Sebastiani, M.; Behrens, C.; Dorr, S.; Gerber, H.D.; Benazza, R.; Hernandez-Alba, O.; Cianferani, S.; Klebe, G.; Heine, A.; Reuter, K.
  ACS Chem Biol (17), 2229-2247 (2022)
  DOI: 10.1021/acschembio.2c00368
  PubMed ID: 35815944
  

• 3,5,7-Substituted Pyrazolo[4,3- d ]Pyrimidine Inhibitors of Cyclin-Dependent Kinases and Cyclin K Degraders
  Jorda, R.; Havlicek, L.; Perina, M.; Vojackova, V.; Pospisil, T.; Djukic, S.; Skerlova, J.; Gruz, J.; Renesova, N.; Klener, P.; Rezacova, P.; Strnad, M.; Krystof, V.
  J Med Chem (65), 8881-8896 (2022)
  DOI: 10.1021/acs.jmedchem.1c02184
  PubMed ID: 35749742
  

• Biochemical and structural insights into an unusual, alkali-metal-independent S-adenosyl-L-homocysteine hydrolase from Synechocystis sp. PCC 6803
  Malecki, P.H.; Imiolczyk, B.; Barciszewski, J.; Czyrko-Horczak, J.; Sliwiak, J.; Gawel, M.; Wozniak, K.; Jaskolski, M.; Brzezinski, K.
  Acta Crystallogr D Struct Biol (78), 865-882 (2022)
  DOI: 10.1107/S2059798322005605
  PubMed ID: 35775986
  

• A Novel NAMPT Inhibitor-Based Antibody-Drug Conjugate Payload Class for Cancer Therapy
  Bohnke, N.; Berger, M.; Griebenow, N.; Rottmann, A.; Erkelenz, M.; Hammer, S.; Berndt, S.; Gunther, J.; Wengner, A.M.; Stelte-Ludwig, B.; Mahlert, C.; Greven, S.; Dietz, L.; Jorissen, H.; Barak, N.; Bomer, U.; Hillig, R.C.; Eberspaecher, U.; Weiske, J.; Giese, A.; Mumberg, D.; Nising, C.F.; Weinmann, H.; Sommer, A.
  Bioconjug Chem (33), 1210-1221 (2022)
  DOI: 10.1021/acs.bioconjchem.2c00178
  PubMed ID: 35658441
  

• Direct interaction of a chaperone-bound type III secretion substrate with the export gate
  Gilzer, D.; Schreiner, M.; Niemann, H.H.
  Nat Commun (13), 2858-2858 (2022)
  DOI: 10.1038/s41467-022-30487-1
  PubMed ID: 35654781
  

• Structural Basis of the Pancreatitis-Associated Autoproteolytic Failsafe Mechanism in Human Anionic Trypsin
  Nagel, F.; Susemihl, A.; Geist, N.; Mohlis, K.; Palm, G.J.; Lammers, M.; Delcea, M.
  J Inflamm Res (15), 3633-3642 (2022)
  DOI: 10.2147/JIR.S367699
  PubMed ID: 35775010
  

• First High-Resolution Crystal Structures of DNA:2'-O-Methyl-RNA Heteroduplexes
  Dolot, R.; Maciaszek, A.; Mikolajczyk, B.; Nawrot, B.
  Crystals (Basel) (2022)
  DOI: 10.3390/cryst12060760
  

• Signal transduction in light-oxygen-voltage receptors lacking the active-site glutamine
  Dietler, J.; Gelfert, R.; Kaiser, J.; Borin, V.; Renzl, C.; Pilsl, S.; Ranzani, A.T.; Garcia de Fuentes, A.; Gleichmann, T.; Diensthuber, R.P.; Weyand, M.; Mayer, G.; Schapiro, I.; Moglich, A.
  Nat Commun (13), 2618-2618 (2022)
  DOI: 10.1038/s41467-022-30252-4
  PubMed ID: 35552382
  

• An anti-diabetic drug targets NEET (CISD) proteins through destabilization of their [2Fe-2S] clusters
  Marjault, H.B.; Karmi, O.; Zuo, K.; Michaeli, D.; Eisenberg-Domovich, Y.; Rossetti, G.; de Chassey, B.; Vonderscher, J.; Cabantchik, I.; Carloni, P.; Mittler, R.; Livnah, O.; Meldrum, E.; Nechushtai, R.
  Commun Biol (5), 437-437 (2022)
  DOI: 10.1038/s42003-022-03393-x
  PubMed ID: 35538231
  

• Molecular insights into RNA recognition and gene regulation by the TRIM-NHL protein Mei-P26
  Salerno-Kochan, A.; Horn, A.; Ghosh, P.; Nithin, C.; Koscielniak, A.; Meindl, A.; Strauss, D.; Krutyholowa, R.; Rossbach, O.; Bujnicki, J.M.; Gaik, M.; Medenbach, J.; Glatt, S.
  Life Sci Alliance (5) (2022)
  DOI: 10.26508/lsa.202201418
  PubMed ID: 35512835
  

• Structure and Mechanism of a Cold-Adapted Bacterial Lipase
  Lund, B.A.; Svalberg, L.; Purg, M.; Chukwu, G.; Widersten, M.; Isaksen, G.V.; Brandsdal, B.O.; Aqvist, J.
  Biochemistry (61), 933-942 (2022)
  DOI: 10.1021/acs.biochem.2c00087
  

• New ligand-binding sites identified in the crystal structures of [beta]-lactoglobulin complexes with desipramine
  Loch, J.I.; Barciszewski, J.; Sliwiak, J.; Bonarek, P.; Wrobel, P.; Pokrywka, K.; Shabalin, I.G.; Minor, W.; Jaskolski, M.; Lewinski, K.
  IUCrJ (9), 386-398 (2022)
  DOI: 10.1107/S2052252522004183
  

• Molecular basis of antibiotic self-resistance in a bee larvae pathogen
  Dang, T.; Loll, B.; Muller, S.; Skobalj, R.; Ebeling, J.; Bulatov, T.; Gensel, S.; Gobel, J.; Wahl, M.C.; Genersch, E.; Mainz, A.; Sussmuth, R.D.
  Nat Commun (13), 2349-2349 (2022)
  DOI: 10.1038/s41467-022-29829-w
  PubMed ID: 35487884
  

• Structure-Based Optimization and Characterization of Macrocyclic Zika Virus NS2B-NS3 Protease Inhibitors
  Huber, S.; Braun, N.J.; Schmacke, L.C.; Quek, J.P.; Murra, R.; Bender, D.; Hildt, E.; Luo, D.; Heine, A.; Steinmetzer, T.
  J Med Chem (65), 6555-6572 (2022)
  DOI: 10.1021/acs.jmedchem.1c01860
  PubMed ID: 35475620
  

• Biotechnological potential and initial characterization of two novel sesquiterpene synthases from Basidiomycota Coniophora puteana for heterologous production of delta-cadinol
  Ringel, M.; Dimos, N.; Himpich, S.; Haack, M.; Huber, C.; Eisenreich, W.; Schenk, G.; Loll, B.; Bruck, T.
  Microb Cell Fact (21), 64-64 (2022)
  DOI: 10.1186/s12934-022-01791-8
  PubMed ID: 35440053
  

• The mycobacterial guaB1 gene encodes a guanosine 5'-monophosphate reductase with a cystathionine-beta-synthase domain
  Knejzlik, Z.; Dolezal, M.; Herkommerova, K.; Clarova, K.; Klima, M.; Dedola, M.; Zbornikova, E.; Rejman, D.; Pichova, I.
  FEBS J (289), 5571-5598 (2022)
  DOI: 10.1111/febs.16448
  PubMed ID: 35338694
  

• Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism
  Dahms, S.O.; Schnapp, G.; Winter, M.; Buttner, F.H.; Schleputz, M.; Gnamm, C.; Pautsch, A.; Brandstetter, H.
  ACS Chem Biol (17), 816-821 (2022)
  DOI: 10.1021/acschembio.2c00103
  PubMed ID: 35377598
  

• Structural and Biophysical Analysis of the Phytochelatin-Synthase-Like Enzyme from Nostoc sp. Shows That Its Protease Activity is Sensitive to the Redox State of the Substrate
  Gisdon, F.J.; Feiler, C.G.; Kempf, O.; Foerster, J.M.; Haiss, J.; Blankenfeldt, W.; Ullmann, G.M.; Bombarda, E.
  ACS Chem Biol (17), 883-897 (2022)
  DOI: 10.1021/acschembio.1c00941
  PubMed ID: 35377603
  

• Crystal structures of apo- and FAD-bound human peroxisomal acyl-CoA oxidase provide mechanistic basis explaining clinical observations
  Sonani, R.R.; Blat, A.; Dubin, G.
  Int J Biol Macromol (205), 203-210 (2022)
  DOI: 10.1016/j.ijbiomac.2022.02.008
  PubMed ID: 35149097
  

• Crystal structure of ArOYE6 reveals a novel C-terminal helical extension and mechanistic insights into the distinct class III OYEs from pathogenic fungi
  Singh, Y.; Sharma, R.; Mishra, M.; Verma, P.K.; Saxena, A.K.
  FEBS J (289), 5531-5550 (2022)
  DOI: 10.1111/febs.16445
  PubMed ID: 35313092
  

• Structural and Biophysical Insights into SPINK1 Bound to Human Cationic Trypsin
  Nagel, F.; Palm, G.J.; Geist, N.; McDonnell, T.C.R.; Susemihl, A.; Girbardt, B.; Mayerle, J.; Lerch, M.M.; Lammers, M.; Delcea, M.
  Int J Mol Sci (23) (2022)
  DOI: 10.3390/ijms23073468
  PubMed ID: 35408828
  

• Structural basis of phosphatidylinositol 3-kinase C2 alpha function
  Lo, W.T.; Zhang, Y.; Vadas, O.; Roske, Y.; Gulluni, F.; De Santis, M.C.; Zagar, A.V.; Stephanowitz, H.; Hirsch, E.; Liu, F.; Daumke, O.; Kudryashev, M.; Haucke, V.
  Nat Struct Mol Biol (29), 218-228 (2022)
  DOI: 10.1038/s41594-022-00730-w
  PubMed ID: 35256802
  

• A Morphing [4Fe-3S-nO]-Cluster within a Carbon Monoxide Dehydrogenase Scaffold
  Jeoung, J.H.; Fesseler, J.; Domnik, L.; Klemke, F.; Sinnreich, M.; Teutloff, C.; Dobbek, H.
  Angew Chem Int Ed Engl (61), e202117000-e202117000 (2022)
  DOI: 10.1002/anie.202117000
  PubMed ID: 35133707
  

• Comparative structural analysis provides new insights into the function of R2-like ligand-binding oxidase
  Diamanti, R.; Srinivas, V.; Johansson, A.I.; Nordstrom, A.; Griese, J.J.; Lebrette, H.; Hogbom, M.
  FEBS Lett (596), 1600-1610 (2022)
  DOI: 10.1002/1873-3468.14319
  PubMed ID: 35175627
  

• The first structure-function study of GH151 alpha-l-fucosidase uncovers new oligomerization pattern, active site complementation, and selective substrate specificity
  Koval'ova, T.; Koval, T.; Stransky, J.; Kolenko, P.; Duskova, J.; Svecova, L.; Vodickova, P.; Spiwok, V.; Benesova, E.; Lipovova, P.; Dohnalek, J.
  FEBS J (2022)
  DOI: 10.1111/febs.16387
  

• A recurring packing contact in crystals of InlB pinpoints functional binding sites in the internalin domain and the B repeat
  Geerds, C.; Bleymuller, W.M.; Meyer, T.; Widmann, C.; Niemann, H.H.
  Acta Crystallogr D Struct Biol (78), 310-320 (2022)
  DOI: 10.1107/S2059798322000432
  PubMed ID: 35234145
  

• Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes
  Benysek, J.; Busa, M.; Rubesova, P.; Fanfrlik, J.; Lepsik, M.; Brynda, J.; Matouskova, Z.; Bartz, U.; Horn, M.; Gutschow, M.; Mares, M.
  J Enzyme Inhib Med Chem (37), 515-526 (2022)
  DOI: 10.1080/14756366.2021.2024527
  PubMed ID: 35144520
  

• Diversification by CofC and Control by CofD Govern Biosynthesis and Evolution of Coenzyme F 420 and Its Derivative 3PG-F 420
  Hasan, M.; Schulze, S.; Berndt, L.; Palm, G.J.; Braga, D.; Richter, I.; Last, D.; Lammers, M.; Lackner, G.
  mBio (13), e0350121-e0350121 (2022)
  DOI: 10.1128/mbio.03501-21
  PubMed ID: 35038903
  

• Structural Analysis of the Outer Membrane Lipoprotein BBA14 (OrfD) and the Corresponding Paralogous Gene Family 143 (PFam143) from Borrelia burgdorferi
  Akopjana, I.; Brangulis, K.
  Pathogens (11) (2022)
  DOI: 10.3390/pathogens11020154
  PubMed ID: 35215098
  

• Structure-Activity Relationship of 3-Methylcytidine-5'-alpha , beta-methylenediphosphates as CD73 Inhibitors
  Scortichini, M.; Idris, R.M.; Moschutz, S.; Keim, A.; Salmaso, V.; Dobelmann, C.; Oliva, P.; Losenkova, K.; Irjala, H.; Vaittinen, S.; Sandholm, J.; Yegutkin, G.G.; Strater, N.; Junker, A.; Muller, C.E.; Jacobson, K.A.
  J Med Chem (65), 2409-2433 (2022)
  DOI: 10.1021/acs.jmedchem.1c01852
  PubMed ID: 35080883
  

• Determining the oxidation state of elements by X-ray crystallography
  Lennartz, F.; Jeoung, J.H.; Ruenger, S.; Dobbek, H.; Weiss, M.S.
  Acta Crystallogr D Struct Biol (78), 238-247 (2022)
  DOI: 10.1107/S2059798321013048
  PubMed ID: 35102889
  

• Identification, functional characterization, assembly and structure of ToxIN type III toxin-antitoxin complex from E. coli
  Manikandan, P.; Sandhya, S.; Nadig, K.; Paul, S.; Srinivasan, N.; Rothweiler, U.; Singh, M.
  Nucleic Acids Res (50), 1687-1700 (2022)
  DOI: 10.1093/nar/gkab1264
  PubMed ID: 35018473
  

• Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists
  Orsi, D.L.; Ferrara, S.J.; Siegel, S.; Friberg, A.; Bouche, L.; Pook, E.; Lienau, P.; Bluck, J.P.; Lemke, C.T.; Akcay, G.; Stellfeld, T.; Meyer, H.; Putter, V.; Holton, S.J.; Korr, D.; Jerchel-Furau, I.; Pantelidou, C.; Strathdee, C.A.; Meyerson, M.; Eis, K.; Goldstein, J.T.
  Bioorg Med Chem (78), 117130-117130 (2022)
  DOI: 10.1016/j.bmc.2022.117130
  PubMed ID: 36542958
  

• Fluorine-induced polarity increases inhibitory activity of BPTI towards chymotrypsin
  Leppkes, J.; Dimos, N.; Loll, B.; Hohmann, T.; Dyrks, M.; Wieseke, A.; Keller, B.G.; Koksch, B.
  RSC Chem Biol (3), 773-782 (2022)
  DOI: 10.1039/d2cb00018k
  PubMed ID: 35755190
  

• A newly introduced salt bridge cluster improves structural and biophysical properties of de novo TIM barrels
  Kordes, S.; Romero-Romero, S.; Lutz, L.; Hocker, B.
  Protein Sci (31), 513-527 (2022)
  DOI: 10.1002/pro.4249
  PubMed ID: 34865275
  

• Visible-Light Removable Photocaging Groups Accepted by MjMAT Variant: Structural Basis and Compatibility with DNA and RNA Methyltransferases
  Peters, A.; Herrmann, E.; Cornelissen, N.V.; Klocker, N.; Kummel, D.; Rentmeister, A.
  Chembiochem (23), e202100437-e202100437 (2022)
  DOI: 10.1002/cbic.202100437
  PubMed ID: 34606675
  

• Inactive pseudoenzyme subunits in heterotetrameric BbsCD, a novel short-chain alcohol dehydrogenase involved in anaerobic toluene degradation
  von Horsten, S.; Lippert, M.L.; Geisselbrecht, Y.; Schuhle, K.; Schall, I.; Essen, L.O.; Heider, J.
  FEBS J (289), 1023-1042 (2022)
  DOI: 10.1111/febs.16216
  PubMed ID: 34601806
  

• Molecular Plasticity of Crystalline CK2 alpha ' Leads to KN2, a Bivalent Inhibitor of Protein Kinase CK2 with Extraordinary Selectivity
  Lindenblatt, D.; Applegate, V.; Nickelsen, A.; Klussmann, M.; Neundorf, I.; Gotz, C.; Jose, J.; Niefind, K.
  J Med Chem (65), 1302-1312 (2022)
  DOI: 10.1021/acs.jmedchem.1c00063
  PubMed ID: 34323071
  

• Structures of the TetR-like transcription regulator RcdA alone and in complexes with ligands
  Pietrzyk-Brzezinska, A.J.; Cociurovscaia, A.
  Proteins (90), 33-44 (2022)
  DOI: 10.1002/prot.26183
  PubMed ID: 34288132
  

• The role of positive charged residue in the proton-transfer mechanism of two-domain laccase from Streptomyces griseoflavus Ac-993
  Gabdulkhakov, A.; Kolyadenko, I.; Oliveira, P.; Tamagnini, P.; Mikhaylina, A.; Tishchenko, S.
  J Biomol Struct Dyn (40), 8324-8331 (2022)
  DOI: 10.1080/07391102.2021.1911852
  PubMed ID: 33870857